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发布于:2018-12-5 18:27:37  访问:131 次 回复:0 篇
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ProBNP values had been normal (51 ?28 pg/l), but they enhanced drastically on
PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25112874 This suggests either a E7046 higher cutoff worth may be expected to adequately make use of the test in an ICU population or it ought to be abandoned completely for patients PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26437915 admitted towards the ICU, particularly in light of such substantial standard deviations regarding the imply. There was a significant correlation between NT-proBNP on days 1 and 2 (P = 0.002), NT-proBNP and daily urinary loss of sodium (P = 0.049) on day 1, and no other correlations were found. Conclusion NT-proBNP values were not increased on day 1 in patients after elective cervical spine surgery, but they were significantly increased on day 2 and there was a significant correlation to daily urinary loss of sodium.NT-proBNP levels. The Kruskal allis test was used to determine significant differences between five specific diagnoses; CHF/ pulmonary edema (both cardiogenic and noncardiogenic), pneumonia, COPD exacerbation, ARF and sepsis. A receiver perator curve (ROC) was used to examine the sensitivity and specificity of CHF at different NT-proBNP cutoff values. Results A total of 47 patients out of 199 (23.6 ) surveyed had NT-proBNP measured. Forty-two of 199 (21.1 ) fit into the diagnostic categories used for comparison. The Kruskal allis test showed among the five diagnoses that only CHF and pneumonia had significantly different NT-proBNP levels (P = 0.0025). The difference in NT-proBNP levels between patients with and without respiratory failure was not significant. Results are presented in Table 1. The ROC analysis showed a ROC AUC of 0.774, but to achieve a specificity >0.9 demands a cutoff value of about 15,000 pg/ml. Conclusion The frequently accepted cutoff for NT-proBNP supporting the diagnosis of CHF is 1000 pg/ml. The typical values within this ICU population (14,114.6 pg/ml) are well above this cutoff worth; 85 had been above 1000 pg/ml but only 12/47 (25.five ) with the sufferers have been diagnosed with CHF. PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25112874 This suggests either a higher cutoff value may possibly be required to correctly make use of the test in an ICU population or it must be abandoned fully for sufferers PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/26437915 admitted towards the ICU, especially in light of such huge regular deviations in regards to the imply. In addition, the data recommend that NTproBNP will not play a part in differentiating the etiology of respiratory compromise.P190 Connection among B-type natriuretic peptide plasma levels and echocardiography parameters in decompensated chronic heart failure sufferers treated with levosimendanMB Ferri, RH Passos, M Knobel, M Nigri, EJA Figueiredo, RD Morsch, P Silveira, JMA Souza, A Perez Hospital Israelita Albert Einstein, Sao Paulo, Brazil Crucial Care 2006, 10(Suppl 1):P190 (doi: ten.1186/cc4537) Background B-type natriuretic peptide (BNP) plasma levels have not too long ago been demonstrated as significant neurohormonal markers of chronic heart failure (CHF) progression and prognosis. Also, clinical studies have shown that the calcium sensitizer levosimendan beneficially impacts the central hemodynamics of CHF patients and improves their long-term prognosis. Objective To investigate whether levosimendan-induced hemodynamic improvement, as confirmed by echocardiogram of CHF individuals, is associated with respective adjustments in BNP levels.
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